NOVOS Reviews

Are you aging well? How can you really know? Maybe you’re keeping your hair for longer than your father did. Or, perhaps, you’re slimmer than your mother was at your age. But aging is such a complex process that these superficial markers can only ever tell us part of the story.

Some tests have been developed over the years that can track markers associated with aging, and numerous companies have developed supplements designed to address poor results on these very tests. The idea is that you can more accurately track your aging process and then take proactive steps to improve it.

NOVOS offers both a test to track your aging and the supplements it claims can improve your results. We ordered them for ourselves, tried them, and compared them to the dozens of other anti-aging supplements we’ve reviewed over the years. Here’s what we found.

Two of the three supplements made by NOVOS are exceptional in their formulation, containing numerous beneficial ingredients, many of which appear at doses that align with successful studies to combat aging. The company’s test is a fascinating outlier among at-home tests that focus on certain aging markers, and it may be one of the most accurate when comparing the results of multiple tests over time — an ideal characteristic to study how you’re aging and whether the company’s supplements are working. The whole package gets pricey fast, but longer billing cycles make pricing comparable to most competitors.

At Innerbody Research, we thoroughly evaluate every product or service we review, including NOVOS. For this review, our team read through nearly 100 scientific journal articles pertaining to aging, age-related testing, and the various ingredients in NOVOS products intended to slow the aging process.

We also leveraged our position as consumers, having reviewed and tested dozens of age-related supplements and at-home tests over the years. We then ordered NOVOS products for ourselves, allowing us to establish direct comparisons to the company’s top competitors.

Additionally, like all health-related content on this website, this guide was thoroughly vetted by one or more members of our Medical Review Board for accuracy and will continue to be monitored for updates by our editorial team.

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.

In evaluating NOVOS, we looked into six criteria that would likely prove the most important for average consumers, specifically:

• Effectiveness
• Safety
• Cost
• Test results
• Convenience
• Taste

We chose to separate effectiveness and test results so we could focus on the potential of the company’s supplements. It’s also possible that a reader could conclude they’d like to try some of NOVOS’ supplements without taking its test, making an independent assessment of its supplements more crucial.

Let’s look more closely at each criterion to see how the company fared:

Effectiveness

Two of NOVOS’ three supplements are driving the positive momentum behind its effectiveness rating, with well-considered formulas offering clinically relevant doses of most ingredients. On their own, many of these ingredients could provide some anti-aging or organ support benefit at the doses NOVOS uses, and they should be even more effective in combination with one another.

NOVOS has some interesting internal research on its supplements that bears out the potential of its ingredient combinations, but there is, of course, a significant possibility of bias with this kind of research. These internal studies are available on the NOVOS website but are not published in any peer-reviewed journal.

NOVOS also has a study on its Core supplement that was conducted by prominent researchers in late 2024 but has yet to be published in a peer-reviewed journal.1 If that study can stand up to peer review, it’ll be a win for the company, as its results indicate slightly superior performance compared to a prescription-strength senolytic and significantly superior performance against a placebo in measuring expected lifespan in mice.

With the NOVOS-specific research awaiting peer review, we drew our conclusions about NOVOS’ potential efficacy by looking at research into its supplements’ individual ingredients. In some cases, research points directly at markers of aging, like cognitive performance scrutinized in a 2023 pterostilbene study.2 In others, it looks at health improvements that, in turn, would support better aging outcomes, as with magnesium studies revealing support for healthy sleep cycles.3 In many of these cases, the doses used in Core and Vital align with or very closely approach the doses used in successful research.

So, why isn’t this a 10 out of 10? Well, some doses are still subpar, and the company’s nicotinamide mononucleotide capsules only provide 250mg of NMN. That’s not too little to be effective, but it’s at the very bottom of what we’ve seen in studies, with 300-1,000mg being a much better range.

Safety

The vast majority of ingredients in NOVOS supplements have been shown to be safe at effective doses. For most people, these ingredients alone or in combination should cause few to no side effects. For example, studies of glycine in mice showed no observable adverse effects at doses as high as 2,000mg/kg.4 That’s a human-equivalent dose of 22g/day, while Core provides just 2g per dose.

You’ll see the same thing in Vital, where something like trehalose has been shown to be safe in doses as high as 50g.5 Vital only contains 4g.

There are ingredients that lack sufficient research into potential risks, however, like rutin or microdoses of lithium. If incoming safety data shows a lack of adverse effects at doses equal to or higher than those in NOVOS supplements, we’ll likely adjust this rating to be higher.

Cost

At first glance, NOVOS seems prohibitively expensive. But its prices are actually average for the market it occupies. Let’s look at Core to get a clearer picture of how it compares to some similar products out there:

Among these options, NOVOS Core is neither the most expensive nor the least expensive, and a deeper dive into its ingredients and doses reveals a well-priced supplement overall. That said, something like AgeMate’s Daily Longevity Blend gives Core a run for its money, offering a slightly longer list of active ingredients for a slightly lower price in the same convenient drink format. Blueprint’s mix is even less expensive, though its ingredient list is shorter and contains fewer of the high-end anti-aging components in NOVOS and AgeMate products.

NOVOS took a hit in the cost department due to its NMN price, as well. Compare the 60 (125mg) capsules that come in each bottle of NOVOS Boost to the 240 (125mg) sublingual tablets that you can get from Renue by Science:

With this price difference, you could effectively double your dose of NMN with Renue and still pay less per dose.

Test results

In addition to its supplements, NOVOS offers an epigenetic test that measures the rate at which your body is aging. These tests typically only tell you an approximated biological age, as opposed to your chronological age (measured in birthdays). A 40-year-old in excellent health may by 40 years of age chronologically, but their biological — or epigenetic — age might be closer to 30. The inverse is also true. That same 40-year-old, if in poor health, could have a biological age closer to 50.

We’ll discuss how these tests work and how reliable they are in general further down the page, but it’s worth noting here that NOVOS uses the Dunedin Pace epigenetic aging method to measure the rate at which you're aging at the time of the test. This can illustrate more accurately than other tests how interventions (e.g., improving diet, increasing exercise) may or may not be affecting your biological age.

However, just because it’s the most reliable option out there, that doesn’t mean it’s perfect. There’s still a margin of error to consider, and the scientific community’s actual understanding of how the epigenetic clock functions is still severely limited. Also, test results take up to six weeks to arrive.

Convenience

Many anti-aging ingredients do their best work at relatively high doses, often measured in grams and not milligrams. Translated to a capsule, that can make for a large number of very big pills to swallow every day. As a result, several anti-aging supplement companies like NOVOS and AgeMate have seen fit to develop more convenient drink mixes that allow them to deliver more effective doses of their ingredients.

Our testers appreciate this added convenience, which you’ll also find in the company’s organ support chews. You have to take four of them, but, as we’ll discuss in a moment, they taste pretty good, and it’s easy to enjoy them.

The NOVOS website also offers a lot of useful resources in its blog and links to relevant scientific research, so you don’t have to spend quite as much time scouring the internet for evidence if you’re of the research-inclined sort.

The big problem with NOVOS from a convenience standpoint is its return policy. It is, frankly, a little ridiculous — both in its rules and in how those rules are presented. There is no money-back guarantee; you can only return unopened goods within 30 days of purchase.

If you do decide to return something, NOVOS states in the same paragraph that it’ll charge you $25 to cover the cost of shipping. You’ll also be on the hook for a $35 restocking fee per transaction. If you’re keeping score at home, that means you could spend $44 on a bottle of NOVOS Boost and actually owe the company $16 if you changed your mind and wanted to return it! Compared to something like AgeMate’s 100-day money-back guarantee (essentially a free trial), this is rather poor.

Taste

NOVOS’ two best products are its Core drink mix and Vital gummies. Since neither is a pill, it’s important that we consider how these two taste.

Let’s start out talking about Core, which combines its active ingredients with erythritol, stevia, malic acid, and natural flavors to provide its taste. In testing, our team found the orange-flavored drink to be very tangy when mixed with the recommended 8oz of water. For some, it was too tangy, so we tried upping the water to 12oz. Interestingly, we found that the beverage became somewhat less enjoyable when it was more watered down. It’s likely that the tanginess is what carries a positive flavor through the experience, and diluting it allows the mix to become somewhat bland. One tester thought the diluted beverage took on a vaguely fermented aftertaste. We’d recommend sticking as close to the 8oz recommendation as you can without it being too tangy for you.

The Vital chews were surprising in several ways. To read about them and see marketing images, you might expect them to behave like gummies, but their texture is markedly different. They’re very soft, with just a hint of stiffness around the outside. Once you bite into them, they dissolve into a slightly sandy texture. The flavor is good — pleasantly sweet and not chalky or medicinal. It’s easy to take the four-chew dose.

NOVOS is a wellness company focused on longevity — specifically on slowing the process of aging. It provides a trio of supplements intended to improve this process and also sells an epigenetic test that measures the rate at which your body is aging. The intent is for you to take a test to establish a baseline of your biological age rate, then start taking the company’s supplements and later retest to measure your improvement.

While numerous individual ingredients are often touted for their potential to support longevity, NOVOS is one of a few companies offering a complete package of testing and formulas containing complex blends of these ingredients.

NOVOS company reputation

NOVOS has yet to establish a concrete reputation for itself, with no reviews posted to its unaccredited Better Business Bureau page and only around 82 reviews on its claimed Trustpilot page at the time of this writing.

Its rating on Trustpilot from those 82 reviews is a 3.7 — above average but not outstanding. Most of the negative reviews involve issues acquiring refunds when seeking them. This tracks with our research, as NOVOS’ stated return policy is one of the worst that we’ve encountered. It includes hefty processing and restocking fees that, in some cases, can be more expensive than the original product.

When we talk about aging, we could easily mean a few different things. For some, fighting aging is all about extending lifespan, living to 88 instead of 85. For others, it’s more about extending the quality of life, living with less pain and disease, regardless of when their life might end. Still others might focus on the way that the passage of time affects their appearance, hoping to slow the visible signs of aging, like wrinkles.

Each of NOVOS’ three supplements is designed to address all of these aging concerns, but they do so in different ways:

• Core: A complex of anti-aging ingredients intended to slow the rate of aging overall
• Vital: A combination of ingredients shown to support the health and function of specific organs throughout the body
• Boost: An NMN supplement that can increase mitochondrial efficiency and improve cellular health

To gain a better understanding of how these supplements might work, we should examine each offering’s ingredient bill and discuss what science is available to support individual ingredients’ roles in healthy aging.

NOVOS Core

NOVOS Core is the company’s central supplement, and it’s the one most explicitly tied to aging and longevity. It contains 12 ingredients, most of which are delivered at doses that meet or exceed what we’ve seen work in published research, at least for certain aging parameters.

Here’s a look at Core’s ingredient list:

• Vitamin C: 100mg
• Calcium: 231mg (from 1,100mg calcium alpha-ketoglutarate)
• Magnesium: 304mg (from 2g magnesium malate)
• Glycine: 2g
• Glucosamine sulfate: 1,000mg
• Rhodiola rosea: 300mg
• L-Theanine: 150mg
• Hyaluronic acid: 100mg
• Fisetin: 100mg
• Ginger root extract: 100mg
• Pterostilbene: 50mg
• Microdosed lithium: 20mg

Some of these ingredients, like magnesium and calcium, will seem familiar to anyone who’s taken a decent multivitamin. But others might be less well-known. Let’s break down the science behind the most important ingredients in this formula, specifically the ones we find to be present at clinically relevant doses:

While some other ingredients in the formula may have compelling research behind them, either there’s too little data at this time or the doses used in NOVOS Core reside below the average minimum effective dose seen in studies. There’s every chance that some of these slightly smaller doses may still be effective, especially in combination with other effective ingredients in the formula. But without data to back it up, we can’t claim they’ll make a meaningful difference.

NOVOS Vital

Many of the ingredients in NOVOS Core seek to combat aging at a whole-body level. Some of those ingredients may have specific positive effects on certain organs or systems, but NOVOS Vital homes in on particular organs or systems with each ingredient. Its seven components are purported to help the gut, brain, eyes, liver, heart, kidneys, and muscles.

Here’s a look at the list:

• Trehalose: 4g
• Inulin: 4g
• Raw apple cider vinegar: 2g
• Rutin: 560mg
• Nattokinase: 200mg
• Lutein: 10mg
• Zeaxanthin: 1mg

Many of these ingredients will be less familiar to the average consumer than some of the components in Core, so let’s take a look at each and see what it might do for the health of specific organs or systems:

There are certainly a few more underdosed ingredients here and some that rely too heavily on animal studies compared to the ingredients in Core, but adding Vital to complete your package from NOVOS might be worth it for the ingredients that have good science behind them and appear in effective doses.

NOVOS Boost

Novos Boost is the company’s nicotinamide mononucleotide (NMN) supplement. NMN is a form of vitamin B3 that converts to nicotinamide adenine dinucleotide (NAD+) in your cells, and elevated NAD+ has been linked with improvements in energy, appearance, and disease biomarkers. However, Boost isn’t the best option out there for NMN.

For starters, Boost’s NMN dose is on the low end of what studies indicate might be effective. A 2022 study, for example, compared 300mg, 600mg, and 900mg daily doses and found that the 600mg and 900mg doses significantly outperformed the 300mg dose.34 There are still studies that show 250mg can have positive health outcomes, but since safety studies have shown 900-1,250mg daily to be safe, it might be smarter to start with a slightly higher dose.35

It’s also worth noting that competitors to NOVOS often include an NAD+ booster (either NR, NMN, or both) in their main products. Both AEON and AgeMate have NAD+ boosters as part of complex anti-aging formulas, offering an opportunity for you to save rather than buy both from NOVOS.

To get a sense of the best NMN products available, you should check out our comprehensive NMN guide.

How quickly are you aging? It seems like a simple enough question to answer; Earth takes a lap around the sun, and you get one Earth year older. That’s your chronological age. But anyone who’s attended a 20- or 30-year high school reunion or just done some curious poking around social media to see how their former classmates are doing might instinctively know something about biological age.

Biological age, unlike chronological age, is a measure of how your body has physically aged over time, regardless of how much time has passed. It's often closely tied to measures of DNA methylation.36

Epigenetic testing often provides you with a biological age, sometimes called a true age or a metabolic age. You might be 40, but if you’re in good health, your biological age might only be 35. You’ve essentially put fewer miles on yourself.

The problem with epigenetic testing is that it’s both extremely complex and relatively recently developed compared to other tests that can imply overall health (like HbA1C or C-reactive protein testing to measure glucose metabolism and inflammation, respectively). Epigenetic testing can also have a wide margin of error, with even the most well-calculated results having an accuracy range of about 1.5 years.37

That range complicates your ability to measure the success of a given intervention. Suppose you were 40, but your biological age test came back and said you were metabolically 45. In that case, you might start eating better, exercising more, and even taking anti-aging supplements.38 You might successfully knock an entire year off your biological age in, say, six months, but if the results were skewed by 1.5 on your initial test, and another 1.5 years on a subsequent test, your six-month retest could come back saying your new biological age is 47! That would be discouraging, to say the least.

For measuring the success or failure of an intervention, testing to measure your rate of aging (i.e., how quickly or slowly you’re accumulating all those miles) is superior to biological age testing. These tests are more sensitive to interventions and are more likely to give you actionable data. The current gold standard among these is the Dunedin Pace rate of aging test, which is what NOVOS employs.39

NOVOS Age also provides you with a biological age and a measure of your telomere length. Telomere length is becoming a popular measure in the anti-aging community, as it combines certain hereditary aspects of your aging process with environmental and behavioral effects at this point in your life. However, the science is still young.40

You’ll also get ages for certain organs and systems, specifically:

• Inflammation age
• Hormone age
• Immune age
• Heart age
• Brain age
• Lung age
• Metabolic age
• Musculoskeletal age
• Blood age
• Liver age
• Kidney age

NOVOS is a good place to start for people with a little extra money to spend on their anti-aging supplements, especially those who want a comprehensive package that includes supplements and high-quality testing and retesting on a subscription basis.

A recent study in Nature Aging pinpointed two ages at which the process of aging seems to take a meaningful leap in speed and intensity, “with substantial dysregulation occurring at two major periods occurring at approximately 44 years and 60 years of chronological age.” That means that NOVOS or similar anti-aging supplements and testing would be even more important for individuals around those two ages.

Also, anyone determined to access a Dunedin Pace-based rate of aging test would find that NOVOS is among the least expensive providers on the market.

Who might want to look elsewhere?

There are certain people who might do better with a competitor or a different approach to combat aging altogether. The very young may be the most obvious cohort, as the 18-24 demographic is likely to have fewer things going wrong that supplements would need to fix.

But other groups might want to reconsider their NOVOS interest, as well. For example, if you were primarily interested in boosting NAD+, there are several companies offering superior NAD+ boosters for less than NOVOS charges.

It would also be wise to avoid NOVOS if you’re deeply unsure of these types of products and you might find yourself seeking a refund. NOVOS has a particularly abysmal return policy that can cost some customers more than they paid for the supplements themselves.

NOVOS products have a pretty good safety profile. Many appear in doses toward the low end of what studies would suggest to be effective, reducing the risk of adverse effects. That said, there are some ingredients with potential side effects we want to address here, and one that may have some stigma associated with it despite not posing a safety risk.

All that said, with seven distinct ingredients in NOVOS Vital and 12 in NOVOS Core, there's always a risk of allergic reactions or contraindications to other medications or conditions. That’s why it’s critical that you speak to your doctor before adding NOVOS or any new supplement to your regimen.

Initial prices for most NOVOS products are on the high side, but those prices per unit come down if you’re willing to subscribe to up to a year’s supply and pay for that year up front. You can also invest in a bundle that includes two NOVOS supplements and its biological age test.

Each supplement is available as a one-time purchase or a monthly, semiannual, or annual subscription. Subscribers save 10, 15, or 27% depending on the length of subscription they choose (and pay for up front).

Here’s a look at how the pricing breaks down for each product:

Pricing for NOVOS Age, the company’s biological age test, is a little simpler. There’s no subscription option, but you can save a little per test by buying more than one at a time.

• One test: $349
• Two or more tests: $299 each

You can also save a significant amount of money by bundling Core, Boost, and Age into the NOVOS Longevity Kit, a subscription to which saves up to $589 compared to subscribing to each component individually.

The prices for the Longevity Kit are:

• One-time: $2,273 (same cost as individual products)
• Subscription: $1,684 ($589 less than individual products)

Unlike most of its competitors, NOVOS allows you to use HSA and FSA cards when making your purchase, which the company claims saves an average of 30% on orders over $200.

Shipping from NOVOS is free, but its return policy is the worst in its class. We detail this in the Convenience section earlier, but the basics are this:

• You have 30 days to start a return.
• All products must be unopened.
• NOVOS will take $25 out of your return for shipping costs.
• You’ll pay a $35 restocking fee per transaction.

That’s up to $50 in fees when something like a one-time purchase of Boost only costs $44. It would be more expensive to return it than to keep it! By comparison, AgeMate offers a 100-day money-back guarantee that lets you try its products for over three months. Blueprint and Perpetua.Life have similar policies, but they only last 30 days.

NOVOS is certainly not the least expensive option when it comes to anti-aging, so you might be curious about competitors in the space or other approaches you could take to slowing down the clock.

A note about single-ingredient supplements: While numerous single ingredients tout anti-aging benefits in studies, so much of the science is so young, and so much of the aging process is so complex, that a product with multiple ingredients in it is far more likely to provide you with noticeable results. As such, we don’t recommend one single-ingredient supplement to fight aging at this time.

Let’s take a very brief look at some of the available alternatives on the market and some other things you might do to fend off the aging process.