Best NAD+ Supplement

Not too many people are eager to grow old, and if you’re worried about losing energy or mental acuity as the years go by, you don’t need to feel hopeless about it. There’s evidence in animal models that NAD+ supplements can help stave off some of the normal effects of aging.1 We don't recommend getting too excited over any product claiming to be the fountain of youth, but you could experience heightened energy levels and focus.2 You might even see improvements in your appearance, such as more youthful-looking skin.25

You don't need to look any further than the biohacking community to realize there's genuine interest in the potential for NAD+ to be a cornerstone in physical maintenance.3 But with that much buzz around it, it can be hard to determine which supplements — and what doses — could be right for you.

In this guide, our team compares several of the most enticing NAD+ boosters so you can make an informed decision. For a quick sense of the landscape, here's a summary of our top picks.

• Best overall: Renue By Science PURE NMN Powder
• Best NMN: Renue By Science PURE NMN Powder
• Best NR: Thorne NiaCel 400
• Best budget pick: Renue By Science PURE NMN Powder
• Most delivery methods: Renue By Science
• Best absorption: Quicksilver Scientific NAD+ Gold
• Best money-back guarantee: Life Extension
• Best high-dose capsules: ProHealth Longevity
• Best for dogs: Renue By Science Pet NMN

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions to live healthier lifestyles.

At Innerbody Research, we extensively test each health product we review, including these NAD+ supplements. All told, our team has spent over 280 hours testing and researching these supplements, including the examination of more than 100 scholarly journal articles pertaining to aging in general and NAD+ metabolism in particular.

We’ve ordered these products for ourselves to be able to report back to you concerning their effectiveness, taste, and customer service quality. Additionally, like all health-related content on this website, this guide was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

Elevating NAD+ — a critical coenzyme for whole-body cellular health — is best done through precursors that transform to NAD+ once in the body. These supplements, typically called NAD+ boosters, often include one of just two ingredients known to boost NAD+, but there’s still a surprising amount of variety among them.

To compare NAD+ boosters, we relied on a simple set of criteria that could apply to any of the market’s top products. There are instances where comparisons for things like cost get a little muddy, but the information here should still add clarity to your understanding of the field and help calcify specific things you want to see in your NAD+ booster.

Specifically, we looked into the following areas, with the greatest influence on our overall considerations coming from the top of the list:

• Effectiveness
• Cost
• Safety
• Convenience

Let’s take a look at each criterion in a little more detail.

Effectiveness

Winners: ProHealth Longevity and Renue By Science

One of the big questions about the effectiveness of NAD+ boosting is the precursor you use to affect it: NMN or NR. Many NAD+ boosters contain just one of those two ingredients to get the job done, making it relatively easy to compare efficacy but looking at each product’s dose. But some companies combine the two or introduce additional ingredients related to cellular health and aging, which can be beneficial but don’t necessarily make one product more effective than another, especially when you compare their respective doses.

We'll get into our reasons below, but we would recommend NMN for most users interested in a straightforward NAD+ booster, thanks to its superior quantity and quality of supportive research, as well as the fact that NMN is metabolically one step closer to cellular NAD+ than NR is. With that in mind, ProHealth Longevity's 1,000mg capsules offer a high and effective dose of NMN in convenient capsules. You could theoretically achieve even more effective results by taking larger amounts from a bulk NMN powder like Renue By Science's PURE NMN, but that may impinge on safety.

Cost

Winner: Renue By Science

Most NAD+ boosters come in powder form, often packed into capsules that dissolve in your stomach. Alternatively, some companies offer them in capsules that can survive that acidic environment and break down only once they’ve reached the small intestines. We far prefer the second variety of capsules, as they ensure the most comprehensive NAD+ metabolism for an ingested booster.

NMN and NR supplements have similar effective doses, so we used the cost per gram to compare prices across companies. Some companies prefer sublingual tablets or drops, which absorb more efficiently and require smaller doses than powders. That makes it harder to create a direct comparison, as does the inclusion of additional ingredients from certain manufacturers, such as trans-resveratrol and apigenin. Still, we were still able to identify Renue By Science as the clear winner in cost per gram in powder, intranasal, and sublingual liquid deliveries.

Here’s how different companies’ capsule delivery methods compare:

And here’s how their more efficient delivery methods compare:

Safety

Winner: Renue By Science

NAD+ boosters are generally safe for short-term use, though we'll get into a few specific concerns regarding long-term risks below. To compare the safety of these supplements with one another, we considered moderate doses to be among the safest. In many studies, 300mg appears to be one of the lowest doses for encapsulated NAD+ boosters that is both safe and effective. Doses as high as 1,200mg/day in humans have been illustrated as safe for use over a six-week period.4 Based on these findings, a dose of 300mg-1,000mg/day for encapsulated NAD+ boosters and some sublingual powders appears to be safe.

Renue By Science offers doses that are well within that moderate range. The fact that it also has so many different delivery methods means you can switch from a tablet to a powder or a liposomal gel in case you might tolerate one form better than another. If you're convinced that NR is the way to go over NMN, we consider Tru Niagen and Thorne to be solid runners-up in the safety department.

It’s also important to note that the vast majority of studies looking at the safety and efficacy of NR and NMN are conducted in rats and mice. Our understanding of short- and long-term NAD+ booster administration in humans is significantly limited, and there is some evidence that artificially influenced NAD+ levels may play a role in cancer development and tumor growth.

Convenience

Winner: Renue By Science

In the same way Renue By Science's various delivery methods add to its safety profile, those methods contribute to the company taking our top spot for convenience. The biggest knock on the company's convenience is its need for a money-back guarantee. Most NAD+ supplement companies have some kind of guarantee, even if it comes with caveats and restocking fees. Still, the tremendous variety of delivery methods far outweighs the lack of a guarantee in our estimation.

If a money-back guarantee is important to you, you might consider ProHealth Longevity. Its lineup has options with lower doses than the 1,000mg dose we often mention in this piece, so you can find the dose that’s right for your needs and rely on the company's 75-day money-back guarantee if you don’t want to stick with it. Life Extension’s one-year guarantee is even more impressive, but the company doesn’t offer as many dose options.

NAD stands for nicotinamide adenine dinucleotide. Without the plus sign, NAD serves as an umbrella term for a group of chemicals, including NAD+. But what does any of it do in the body?

NAD is a coenzyme integral to the function of our mitochondria — often referred to as the powerhouse of the cell. Efficient mitochondrial function means better cell performance and waste removal.5 The amazing thing about boosting mitochondrial efficiency is that it affects just about every part of your body. That means NAD can address multiple systems without the need for you to take a dozen different supplements.

NAD+ is available as a primary ingredient in some supplements, but our understanding of NAD+ metabolism indicates that its bioavailability is severely limited compared to a pair of its precursors: NMN and NR.6

By using NAD+ precursors instead of NAD+ itself, you can end up with more NAD+ available for your body to utilize. But there's plenty of disagreement about which precursor is the safest and most effective. Understanding how each precursor works helps us understand how vitamin B3 transforms into NAD+ in the body.

The body makes most of its NAD+ from two sources: tryptophan and vitamin B3. While niacin and nicotinamide are among the most popular forms of B3 used in common vitamin supplements, a third form of B3 — nicotinamide riboside (NR) — converts into NAD+ more efficiently in the body.

But NR doesn't just magically become NAD+. It first makes its way into your cells and becomes nicotinamide mononucleotide or NMN, which then becomes NAD+. That's the purported advantage of NMN: it's one step further along the path to becoming NAD+.

NMN vs. NR

So, if NMN becomes NAD+ more directly than NR, why bother with NR at all? Until recently, research showed that exogenous NMN had to become NR to enter human cells before it could go back to NMN and eventually NAD+. That would be relatively inefficient.

More recent studies have shown that there is a specific amino acid and polyamine transporter that's extremely selective for NMN and allows it to enter a cell without first becoming NR.7

Concentrations of this transporter in the guts of mice appear to increase with age, suggesting that the body tries to get extra NMN from its food supply to compensate for deteriorating levels of NAD that coincide with aging. It also indicates that NMN's NAD+ production may be more closely tied to the activity and health of the microbiome than was previously thought. But proving this requires a tremendous amount of additional research.

The bottom line is that both NR and NMN can increase levels of NAD+ in the human body.8 Which one you ultimately choose may have to do with your tolerance for either. If the body becomes better able to absorb NMN directly as it ages, older individuals might want to consider NMN over NR.

We believe NMN has a slight advantage based on the research we've reviewed and our own internal usage. Testers typically felt more energized after consuming NMN than NR, though it’s important to remember these are anecdotal findings. But, again, you may find more pronounced effects from NR, as the differences may come down to individual factors like genetics and age.

NMN FDA status

If you’ve been looking into NMN for any length of time, you might be aware of its controversial standing with the FDA. To be clear, this has nothing to do with any safety concerns on the FDA’s part. Rather, an unintended consequence of a recently adopted law results in the revoking of an ingredient’s supplement status if that supplement is being investigated for a new drug application, regardless of that supplement's status in the marketplace.

Products like CBD and N-acetyl cysteine (NAC) are in the same camp as NMN here, with a few pharmaceutical companies investigating refined versions of these ingredients for possible new drug applications. NMN, CBD, and NAC are all still on the market because the FDA understands that its enforcement discretion is the only thing keeping drug makers from investigating patented versions of everything from vitamin C to St. John's Wort as a way to eliminate competitors and corner the markets of all supplements. So, the FDA, for now at least, allows NMN and similar supplements to be sold openly on the market.

How NAD+ supplements absorb

Absorption can dramatically affect the power of an NAD+ supplement. Some companies use traditional capsules filled with a dose of NMN or NR in powder form. Others compound their supplement powder with liposomal technology that uses fats to protect it from degradation in the GI tract. And still others use sublingual powders, drops, lozenges, and even nasal sprays to increase absorption.

Those more efficient delivery methods tend to use lower doses than capsule powders since your body is likely going to get more out of them. Consider the 50mg NMN dose in Quicksilver Scientific’s NAD+ Gold as compared to the 1,000mg capsules from ProHealth Longevity. The difference isn’t exactly 950mg, as the sublingual liquid will make it to the bloodstream more efficiently. Unfortunately, the precise compounding process for such a liquid is unique to each company, so determining the exact difference in efficacy is impossible without obtaining proprietary information. This may make capsules a more attractive proposition if you want to know your dosage as accurately as possible.

To date, the only human studies looking at NAD+ production from NR or NMN supplementation utilize pretty normal capsules with no special coatings or other technologies included to protect against stomach acid. We know that there is a specific transporter in the small intestines dedicated to metabolizing NMN, so bypassing the stomach here would theoretically yield superior results.9 But there isn’t enough science to back this up yet.

Once they get into the body, NMN and NR make their way into your cells through various complex pathways that will result in different levels of efficacy for just about everyone who takes them.10 Short of taking each on its own for at least a few weeks, it will be difficult to determine which option is best for you. But given a slight edge in research and its superior position on the NAD+ metabolism pathway, we think NMN is a better place for most people to start.

Supporting ingredients

While many companies sell NAD+ boosters on their own, others see fit to pair NMN or NR with additional components. In some cases, the added ingredients are there to help the NAD+ booster work or absorb more effectively. In other cases, they offer complementary benefits to those NAD+ boosters provide, such as anti-aging and anti-inflammatory activity.

Here’s a quick look at the most common supporting ingredients you’ll find in NAD+ boosters:

In the short term, NAD+ supplements appear to be safe and well-tolerated. As with many forms of vitamin B, NR can cause some flushing, and both NR and NMN can cause digestive upset. But these side effects are rare and usually quite mild.

There are no long-term studies examining the safety of NR or NMN. Right now, our understanding of NAD+ is significantly incomplete. The supplement industry talks about it as though it's the fountain of youth, but cancer researchers have successfully starved tumors of the fuel they need to grow by limiting the presence of NAD+.16

It's entirely possible that NAD+ can stave off the onset of various age-related disorders while also contributing to the growth of cancers in the body. For now, we recommend using NAD+ supplements with care. Seek advice from your doctor before starting an NAD+ supplement, especially if you have a personal or family history of cancer.

Best overall, best NMN, best budget pick, most delivery methods, and best for dogs

Renue By Science is one of our top picks, thanks largely to its wide variety of products and delivery methods. The company sells NR and NMN supplements in capsules, tablets, powders, and sublingual drops. Many of these products contain NR or NMN processed in a liposomal format that protects them against stomach acid and allows them to get the most out of the specific NMN transporter found in the small intestine.

Renue By Science also has a line of products it calls NAD+ optimizers. These don’t include the same ingredients you’ll find in boosters, as they’re not meant to increase NAD+ production but rather to help the body retain and employ the NAD+ it already has. These include:

• Trans-resveratrol
• CoQ10
• Apigenin
• Glutathione
• Berberine
• Quercetin
• Fisetin
• Spermidine

These and other NAD+ optimizers are available as standalone supplements or as part of blends with specific targets like morning alertness or anti-inflammation. The science behind some of these supplements is even stronger than the research into NR and NMN, but research into how they react with increased NAD+ levels is not yet available.

If you aren't sure whether you need an NAD+ supplement in the first place, or you don't know how much you might need to increase your NAD+ production, you can take one of Renue By Science's blood tests. You'll perform a finger prick at home and send your sample to a lab directly. From there, you should get results in about a week.

Ideally, you should discuss these results with your doctor, as there is no defined ideal for NAD+ levels related to specific diseases.

Renue By Science offers the following blood tests:

• CoQ10 (antioxidant): $59
• hs-CRP (inflammation): $59
• IC NAD+ (intracellular concentration): $248

These are unusual in the NAD+ booster space. A few similar companies offer testing, like Thorne’s biological age test, but none are as specific to NAD+ as Renue By Science’s offering.

Here's a breakdown of our favorite NAD+ boosters from Renue By Science:

Renue By Science has a subscription program you can join with any purchase that automatically bills and delivers new products every one, two, or three months. You’ll save 5% on subscription orders, which is nice, but it pales in comparison to other companies’ subscription discounts, like the combination of bulk and subscription discounts from Elysium which can save you up to 33%. Still, many of Renue By Science’s products are priced low enough to compete with those deeper discounts.

Quicksilver Scientific is the only other company in our guide to offer a sublingual delivery system. Its NAD+ Gold and Platinum products are like Renue By Science’s LIPO Gel; they’re oil solutions administered under the tongue. Renue By Science adds resveratrol to its formula for a synergistic effect, while Quicksilver Scientific includes betaine, which provides fuel for the methylation process integral to NAD+ metabolism. Renue By Science’s gel is a little more expensive, but you get five times the volume and more than seven times the NMN.

Renue by Science has improved its return policy over the past year. In the past, you could only return unopened product, but now, you are protected by a 60-day money-back guarantee. At the same time, Renue By Science reduced the policy period from 90 days to 60 days. The duration of the return period is not as generous as some competitors like ProHealth Longevity, which offers a 75-day guarantee, or Life Extension, which lets you try its products for up to a year. But we're happy to see that the policy, in general, is much more protective for you.

Best NR

Thorne does an excellent job combining its testing infrastructure with its supplement offerings. You can take at-home tests for general wellness under the company’s Essential and Advanced Health Panels, or look at more specific parameters such as:

• Fertility
• Gut health
• Biological age
• Menopause
• Sleep
• Stress
• Thyroid health
• Vitamin D levels
• Weight management

Thorne offers corresponding supplements for all of its tests, but it also has some supplements for which it lacks testing. Among Thorne's supplements intended to address the results of these tests, you'll find:

Unfortunately, one of the supplements without a directly corresponding test is Thorne’s NR supplement, NiaCel. The closest thing you can take to something like Renue By Science's IC NAD+ test is Thorne's Biological Age Test. If you score poorly, there's a possibility that increasing your NAD+ levels with its NiaCel 400 NR supplement (or any NAD+ booster) could be wise.

NiaCel is available in 207.5mg and 415mg doses. Here's how they price out:

As you can see, in addition to its NR, Thorne's NiaCel also includes a moderate dose of betaine, also known as trimethylglycine (TMG), a natural compound made in the body. TMG can provide the additional material for methylation that’s critical to NAD+ metabolism, potentially increasing the efficacy of any NAD+ booster that includes it.19 You’ll see it in several other products in our guide, and Thorne’s dose is around the median among them.

Ground shipping from Thorne is free, but you have two expedited options if you'd like to receive your purchases more quickly:

• Two-day shipping: $15
• Overnight shipping: $20

Best absorption

Much of what Quicksilver Scientific has to offer is designed for longevity. There are anti-inflammatory supplements, as well as products to increase collagen production, balance hormones, and regulate digestion. The company bundles many of these together, which would save you money if you wanted several of its products on a regular basis, but the sticker prices on many bundles are rather high.

Quicksilver Scientific has two NAD+ boosters: NAD+ Gold and NAD+ Platinum. Here’s how the ingredients and doses compare in each:

As you can see, both formulas contain TMG (trimethylglycine). TMG is a methyl donor, which means it can provide the carbon and hydrogen necessary for methylation — a process vital to NAD+ metabolism.11 Both formulas are also meant to absorb under the tongue to quickly enter the bloodstream, but they’re also liposomal, meaning that the ingredients are protected by a lipid layer that guards them against stomach acid and promotes superior absorption through the small intestines. So, the portion of the product you end up swallowing theoretically has a good chance of absorbing down the line.

NAD+ Gold comes in a convenient pump bottle in either a 30ml or 50ml size, while NAD+ Platinum is only available in a much larger, 100ml bottle with no pump. For this reason, and because Platinum relies partially on a proprietary blend, we recommend NAD+ Gold for most people.

One big drawback with either is that you have to refrigerate the bottle to keep the NMN mixture fresh and effective. This makes returns impossible and prevents you from being able to take your supplements on the road if you travel. Interestingly, Renue By Science’s sublingual NMN gel, which offers a much higher NMN dose per serving and is priced more favorably than NAD+ Gold or Platinum, does not need to be refrigerated for 30 days after opening.

When the box from Quicksilver arrived, we hadn’t been given any notifications that the package was out for delivery or that it had been delivered, and the sticker reading “Refrigerate Upon Receipt” was small and adhered to only one side of the box. We found this to be a recipe for spoiled products if you take the box in without realizing what’s inside and let it sit for too long. We hope Quicksilver can update its shipping logistics to include better package labeling and more tracking notifications.

NAD+ Gold and Platinum are available as one-time purchases or on a subscription basis. You can also get them as part of several bundles offered on the Quicksilver site. Here’s how the pricing for NAD+ products alone breaks down:

Quicksilver Scientific calculates your shipping charges based on location. You can get free shipping on orders over $99, but single bottles of any of the company’s NAD+ products don’t meet that threshold.

Best high-dose capsules

ProHealth Longevity offers several supplements designed with the goal of fighting the aging process and providing you with extra energy. Its NMN supplements come in various forms, so you can choose which one you find easiest to take or decide based on absorption efficiency. Powders and lozenges will be the most efficient, and you can buy powders in bulk sizes up to one kilogram.

One of ProHealth Longevity’s most compelling products is its NMN Pro Complete, which combines a 1,000mg dose of NMN with 1,000mg of trans-resveratrol and 500mg of TMG. Those are the two largest doses of those supporting ingredients you’ll find in this guide. It’s around the same price as our top pick from Renue By Science, but it doesn’t have quite as many doses overall. It’s also possible that such higher doses may result in likelier adverse effects like gastrointestinal distress.

Here's a closer look at ProHealth Longevity's NMN offerings:

You can take 10% off of any of these prices by signing up for ProHealth Longevity’s subscription program, which allows you to set your deliveries for every 30, 60, or 90 days.

Free shipping kicks in once you’ve spent $30 or more, which is a low enough threshold to apply to any of the company’s NMN products.

ProHealth Longevity offers the second-best money-back guarantee of the supplements on this list. Its 75-day policy is long enough to let you try its NMN for over two months to see if it makes you feel any better. It’s not as long as Life Extension’s one-year policy, however.

Life Extension sells a lot of different supplements. Its range is so broad that the company offers a convenient quiz to help you figure out which ones you might need. For anyone interested in NAD+ supplements, Life Extension offers two products that contain NIAGEN, the form of NR you'll find in Tru Niagen — a competing product. Chromadex, the company that owns the NIAGEN patent, also owns Tru Niagen, but it appears to have given rights to Life Extension to sell its NR under another banner.

Life Extension’s 30-count bottle of just Niagen is a little less expensive than Tru Niagen, but Tru Niagen’s bulk purchasing options result in superior savings.

Life Extension's NAD+ Cell Regenerator and Resveratrol combination offers a handful of ingredients in addition to Niagen and Resveratrol. These include:

• Bio-Quercitin 15mg, a flavonoid good for immunity and cardiovascular health20
• Fisetin, a flavonoid good for bone health and anti-inflammation21
• Fenugreek, a botanical ingredient with anti-inflammatory and antioxidant benefits22

Here's what Life Extension NAD+ price structure looks like:

Orders over $50 receive free shipping, as do any subscription orders. If you wish to make a one-time purchase that falls short of the $50 threshold, you’ll pay the following rates:

• Basic: $5.50
• UPS 2nd Day Air: $12.50
• UPS Overnight: $21.50

Life Extension's other products include supplements for:

• Bone health
• Memory and cognition
• Sleep
• Eye health
• Sexual wellness
• Mood support
• Inflammation
• Liver health
• Stress management

Life Extension offers the greatest variety of lab testing among its peers. Any tests requiring a blood sample will need you to go into a LabCorp facility to have blood drawn. The tests from Renue By Science, by comparison, let you collect blood from a finger prick at home.

Life Extension tests can measure things like:

• Testosterone
• Autoimmune response
• Allergies
• Vitamin and mineral concentrations
• Stress indicators
• Nutrient concentrations
• Bowel inflammation
• Iron concentrations
• Food sensitivities
• Blood sugar

All told, there are over 200 tests available to you from Life Extension, each with its specific price. Costs can range from around $20 up into the hundreds. For more on Life Extension, you can check out our full review here.

Elysium offers fewer supplements than some of the competition, but its products are well-made and thoroughly tested. You can access third-party testing results for every manufacturing lot the company produces. That means you can compare the lot number on your bottle of any Elysium product to the list online and read test results specific to the pills in your hand. Other companies boast third-party testing, like Cybiotika’s year-long analysis, but few offer publicly available results like this.

Elysium Basis is the company's NR supplement. In addition to nicotinamide riboside, Basis includes pterostilbene — a potent antioxidant found in blueberries. Combined with NR, it helps prevent oxidative stress that can damage cells and potentially speed up aging.

Basis was the subject of a clinical trial including 120 participants across an 8-week span.26 Elysium funded the study, so there is a potential for bias, but the study itself was performed by a third-party organization. The study saw a 40% increase in NAD+ levels for the group taking the recommended dose compared to placebo. These results are impressive but not out of step with the results of many NR studies.

Here's what Elysium Basis costs:

• One-time purchase: $60
• Monthly subscription $50/month
• Semi-annual subscription: $45/month
• Annual subscription: $40/month

While these are the product's monthly costs, a semi-annual subscription will charge you every six months, and an annual subscription will charge you every year. It’s a nice opportunity to save money that few other companies offer, but there’s a catch. If you want to cancel your annual subscription three months in, you won't get any of your money back. Instead, the company will continue shipping Basis to you every month until your prepaid subscription period ends.

Elysium Basis is also available as part of the company’s Healthy Aging Starter Pack, which gives you all four of its supplements for $199.

Cymbiotika is a wellness company with a wide variety of products. It sells just about everything from green mixtures and probiotics to NAD+ boosters and even a shower filter. It avoids GMOs, fillers, or other artificial ingredients in its goods. And for its consumable goods, the company submits to 12-month-long third-party testing.

The company’s NAD+ booster is an NMN capsule that falls under its anti-aging category. It has more ingredients in it than most NAD+ boosters out there. The full list includes:

• NMN: 400mg
• Apigenin 98%: 200mg
• Green tea leaf extract (20% L-Theanine): 200mg
• Resveratrol (98% trans-resveratrol): 100mg
• Green coffee bean (10% caffeine): 100mg

Apigenin is the ingredient you're least likely to see in other NAD+ supplements. It's a flavonoid you can find in many plants, including chamomile. It has sedative properties, potentially decreasing your overall stress levels that can also hack away at years of your life. At least one study describes the various ways apigenin is being investigated to play a role in preventing and treating diabetes, amnesia, Alzheimer's, depression, and even cancer.23

A one-time purchase of Cymbiotika's NMN supplement is a little pricey, coming in at $77. Still, its ingredient profile is unique for the space, and 200mg of apigenin is an impressive dose for the price point. Just compare that to the 35mg apigenin from Renue By Science — a company typically ahead of the curve on price — that costs $50.

If you're interested in this product, we recommend joining the Subscribe & Save monthly shipment plan, which brings the cost down to $69.30/month. Bundling is another way to save, especially if several Cymbiotika products speak to you. When you bundle, you save 10% off any two items and another 5% off your order for each additional item. Savings will accumulate up to 30%.

Tru Niagen is likely the foremost name in NR supplements. Its specific nicotinamide riboside — branded NIAGEN — has been the subject of several studies. Study participants who have taken it saw definite increases in NAD+ levels. We should note that many of those studies looked at doses above what Tru Niagen provides in a serving, sometimes reaching more than three times that quantity.

Original Tru Niagen is available in 150mg and 300mg capsules, as well as a powder you can dissolve in water to make a drink. The powder stick packs are the most expensive form of Tru Niagen, likely due to the added packaging and processing to make the substance dissolve nicely. The company also makes something called Tru Niagen Pro, which provides a 500mg dose that’s rather difficult for laypersons to purchase, as Tru Niagen doesn’t sell it to consumers directly.

Tru Niagen recently came out with an immunity support supplement called Tru Niagen Immune that combines a 150mg dose of NR with vitamins D and C, zinc, and a curcumin derivative that’s more bioavailable than typical curcumin supplements. Here’s a quick look at the doses:

• NIAGEN:150mg
• Theracurmin: 30mg
• Vitamin C: 180mg
• Vitamin D3: 50mcg
• Zinc: 20mg

The company sells a bundle of the two supplements together, which would take your effective NR dose up to 450mg/day. That’s as close to the company’s Pro formula (500mg) as you can easily get, and with the added ingredients in Tru Niagen Immune, it may be a superior offering.

Here's how a package of Tru Niagen's products price out:

To read more about Tru Niagen and its offerings, you can check out our comprehensive review.