Photo by Innerbody Research
Nearly two-thirds of Americans experience at least one gastrointestinal (GI) problem daily,1 and about eight million annual trips to the emergency room are related to GI concerns.2 Yet these problems often never receive a diagnosis, and even the lucky few with diagnoses don’t often receive treatment that alleviates their symptoms. When irritable bowel syndrome (IBS) feels more like a catch-all diagnosis, mounting frustrations with modern medicine might spill over, worsening your symptoms.
Some attribute chronic GI distress to leaky gut syndrome, a constellation of symptoms related to separations in cells in the intestinal walls. While many medical doctors don’t yet recognize the condition, GI health supplements offer some hope for those suffering.
Among other tests and nutritional changes, adding a GI health supplement — particularly those labeled as “leaky gut supplements” — to your daily routine might mean the difference between feeling uncomfortable and having an easy start to your day. We’ve rounded up the top five best leaky gut supplements and analyzed them in this guide.
Don’t have enough time to read the entire article right now? Check out our top picks below.
Terra Origin Healthy Gut combines high-powered gut-healing ingredients into a delicious powder.
Terra Origin includes several ingredients shown to boost gut health. Choose between eight great-tasting flavors, and enjoy free shipping on orders over $50. Purchases are covered by a 100% satisfaction guarantee.
At Innerbody Research, we extensively test each health service or product we review, including leaky gut supplements. Our team has spent more than 630 hours studying gut health, poring over hundreds of scientific journal articles pertaining to intestinal permeability, the microbiome, and digestion as a whole. We’ve also heavily researched the most commonly recommended leaky gut supplements and examined other possible avenues of treatment with supplements mainly used for other purposes. Our assessments of customer service, shipping logistics, and other aspects of the purchase process come from our experiences ordering the products ourselves.
Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy. We’ll continue to monitor the gut health landscape for developments in leaky gut research and treatments to keep this content current.
Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.
Evaluating leaky gut supplements required us to consider several factors that would mean the most to the average consumer. These four criteria are effectiveness, safety, cost, and convenience, all of which should give you the best sense of what could fit your needs. Let’s take a closer look at each category to see what supplements rose to the top.
Winner: Terra Origin
Finding the right combination of ingredients for your leaky gut symptoms is hard. Since everyone’s body is different and symptoms might come from several causes, the right blend and balance can vary significantly between people. So, while the best leaky gut supplement may not work for everyone, the one that ranks highest in efficacy will specify well-researched ingredients like glutamine and zinc in effective doses without fillers, proprietary blends, or overpromising results.28 35
NatureM.D. and Terra Origin have highly similar ingredient lists. They both have 5g of L-glutamine and substantial amounts of zinc (NatureM.D. has 3mg; Terra Origin has 2.15mg). Terra Origin has more N-acetyl-D-glucosamine (NAG), slippery elm, and marshmallow root, and NatureM.D. contains more quercetin and licorice root, but each difference in ingredient strength is only a matter of 50-100mg. However, NatureM.D.’s formula has a shorter ingredient list, and some beneficial ingredients are left out to ensure it remains a viable option for vegans. As a result, we give the effectiveness category to Terra Origin.
Winner: Terra Origin
Your GI system is one of the most important parts of your body. You have more frequent, direct interactions with it — and control over it — than with almost any other internal organ or system. When you’re experiencing leaky gut symptoms, it’s especially important that anything you put into your gut is safe. When we evaluate a product for safety, we look at its ingredients and dosing (including fillers and additives), testing measures, and manufacturing processes, as well as how much information about the product the company is willing to share with its customers.
Most of the supplements in this guide offer comparable safety profiles, with relatively low doses of most ingredients that are well below what studies show can cause adverse reactions. Part of the reason we gave the edge to Terra Origin is that it’s:
But many of those things can be said of Terra Origin’s competitors. So, then, why Terra Origin? It was a subtle aspect of Terra Origin’s ingredient list that showed us the company’s concern for its customers in the formulation of its product: copper.
Zinc is a common ingredient in leaky gut supplements, as several impressive studies support its ability to help repair and maintain tight junctions in the intestines. But zinc supplementation can deplete copper levels, and Terra Origin is the only product on our list to include copper in its formula as a way of offsetting this potential for deficiency.3
We want to reiterate here that Terra Origin contains NAG, which often derives from shellfish, so the product’s safety doesn’t extend to people with a shellfish allergy.
Winner: Revive Glutamine
When it comes to a supplement’s cost, we consider several factors. Is the supplement offered at a relatively low price, and do you receive a decent amount of it for what you pay? Are there other deals, savings, and subscriptions you can opt into for an even lower price? Do you have multiple purchase options to find the best deal?
As we mentioned in our efficacy section, glutamine is among the most thoroughly studied supplements for gut health, and there’s a generous amount of scientific evidence to support its role in treating a leaky gut. For that reason, a simple glutamine supplement may be enough for many people. You can get Revive Glutamine for $19.99/month with or without a subscription — less expensive than anything else on our list — and its 10g serving of glutamine is twice as much as the next best supplement. It may lack other useful ingredients such as zinc, but it has the potential to be effective for many, and its price can’t be beaten.
Winner: Gundry MD Bio Complete 3
Gut health supplements often come in capsule or powder form. Powders are slightly easier for your body to absorb, but a supplement is only convenient when it’s easy for you to take and dose, too. Taking multiple capsules or measuring an odd fraction of a teaspoon for proper dosing gets complicated and only worsens if there are strict rules about when and how to take the product.
None of our top picks are perfectly convenient, but Gundry MD Bio Complete 3 comes close. You need only two capsules a day to maintain good gut health, and you can take them at any time of day with just a glass of water (preferably before a meal). Seed’s DS-01 Daily Synbiotic also requires just two capsules, but it’s suggested that you take them on an empty stomach (i.e., first thing in the morning), which adds a layer of vigilance on your part that may be inconvenient.
Another convenience measure that Gundry MD offers over our other recommendations is a lengthy money-back guarantee. Some of the supplements in this guide have no guarantee, just short return windows for unopened products. Terra Origin offers a 30-day money-back guarantee, but leaky gut supplements don’t always work that quickly. Gundry MD’s 90-day guarantee allows you to try its products for three months before making a determination about them.
To help you understand the similarities and differences among our top picks, we’ve created a chart that breaks down all the information you need. We’ve used the cost of a one-time purchase for each (except for Seed, which is subscription-only) and included potential savings options:
Leaky gut is more formally known as increased intestinal permeability or decreased intestinal mucosal barrier function.4 The term “leaky gut” has been used to describe a set of general GI symptoms related to issues with your intestines “leaking” toxins and bacteria into your bloodstream as they process food. Specifically, leaky gut is often associated with:
Some people believe that a leaky gut on its own is the cause of their GI problems, referring to it as “leaky gut syndrome.” While the theory that it’s a separate diagnosable disease is becoming more popular, it hasn’t really been embraced in contemporary Western medicine, and leaky gut syndrome isn’t typically something with which a doctor will diagnose you. Most doctors can’t administer formal and reliable tests to check for a leaky gut, and since it can be indicative of many GI diseases, it’s more likely that you’ll be tested for things like celiac and Crohn’s disease if you present with the above-listed symptoms.
Special Offer from Terra: FREE Shipping On Orders Over $25
So, leaky gut involves a degradation of your gut’s mucosal barrier, but what causes it in the first place? To understand that, we need to investigate the mucosal barrier and what it does.
Every inch of your intestinal tract is covered in a mucosal barrier. This physical barrier helps keep the lumen — the inside of your intestines — separate from the rest of your body. A normal intestinal mucosal barrier is full of several different kinds of cells, which all work together to absorb nutrients and keep things moving through your intestines. The protein zonulin helps to mediate this permeability as well.57 Tight junctions connect your intestinal cells, regulating the movement of water and other substances through your GI tract.
When your mucosal barrier is compromised, those tight junctions between cells in the intestinal walls open up, leading to small gaps where bacteria and other toxins can move freely. Leaky gut is thought to occur when these tight junctions open up relatively widely, allowing for a greater influx of harm to the intestinal tract. This hyperpermeability can expose your bloodstream to bacteria and other toxins and may affect the contents of your gut microbiome.
There are dozens of different reasons that your intestinal barrier could be weakened. These include (but aren’t limited to):
A leaky gut could also indicate more complex health concerns, such as:
Despite some claims, leaky gut doesn’t appear to be related to autism, depression, anxiety, or skin problems like eczema. That said, there is a strong link between gut health and mental health due to the number of neurotransmitter receptors across the digestive system, so poor gut health can affect how you feel.27
Leaky gut supplements are designed to help quell your symptoms and rebalance off-kilter gut properties. There are three main places and mechanisms that leaky gut supplements support:
Leaky gut supplements contain many ingredients to ease digestion, support your intestines, and bolster your gut microbiome. We’ve rounded up some of the most common ingredients so you can understand exactly what they do to help.
Glutamine is the most common amino acid in your body and one of the most critical nutrients for soothing leaky gut symptoms. It’s made in your muscles and used in all parts of your body to create proteins and other amino acids. In your GI system, it’s used as fuel for your intestinal cells and has anti-inflammatory effects, both of which are necessary for well-rounded mucosal barrier function. It also helps keep tight junctions together, preventing bacteria and toxins from slipping out and playing a core role in your intestinal permeability.28
Your gut microbiome is made of billions of good bacteria that help fight off harmful bacteria, send food from your stomach to your intestines, and perform a host of other protective functions. Taking probiotics adds more good bacteria to your system, improving your digestive health and preventing the overgrowth of bad bacteria.74 Research has shown that good bacteria can, in some cases, reverse the symptoms of leaky gut by bolstering tight junction proteins, though researchers are still working to understand exactly how that works.29
Like probiotics, prebiotics work to improve your gut microbiome’s health. Prebiotics are food for the healthy bacteria in your microbiome, stimulating their growth. Most prebiotics are made from carbohydrates found in plant fibers that your body can’t otherwise digest. By feeding the good bacteria in your gut, prebiotics help to promote the growth of good bacteria and prevent the overgrowth of bad bacteria.30
Your body naturally makes digestive enzymes, which break down your food so you can access its nutrients, but a leaky gut can deplete how many enzymes you can access. Adding digestive enzymes like amylase,31 lipase,32 and protease can start the breakdown process before food reaches your compromised intestines, ensuring that you’re still getting most of the necessary nutrients from your diet.33
Having too little zinc can worsen your intestinal permeability.34 For more than two decades, clinical researchers have known that adding zinc to your diet can reinforce tight junctions.35 Zinc helps maintain a robust immune system, promote cell growth, build protein, and heal damaged tissue, all of which can improve the symptoms of leaky gut.34
Tryptophan is an essential amino acid. It may be better known for making you sleepy after eating turkey on Thanksgiving, but a recent discovery also points to its protective role against leaky gut.36 Not having enough tryptophan can shrink your gut microbiome and increase systemic inflammation. Increased intestinal permeability has been linked to lower levels of tryptophan for those very reasons, so keeping your dietary tryptophan intake stable can help prevent inflammation that loosens tight junctions.37
Your body creates vitamin D when it gets enough exposure to sunlight. It’s critical for daily functioning, yet about 80% of people have some level of vitamin D deficiency. The vitamin helps to build and maintain bones, protect your nervous system, and keep your immune system working its best. In the GI system, vitamin D plays an integral role in diversifying your gut microbiome, ultimately protecting your intestines from damage.38
Magnesium, like other minerals, has a cyclical relationship with leaky gut: not having enough can make inflammation happen faster, and more inflammation means you absorb less magnesium through your diet. It also plays a secondary role by improving fatigue, a common leaky gut symptom.39 Supplementing magnesium can help to quell the inflammation, but be warned that too much of certain types of magnesium can have a laxative effect by increasing the amount of water moving through your intestines.
Omega-3 fatty acids are found in many foods but are most common in fish, crustaceans (like krill), walnuts, and flaxseed. While there’s still research to be done on exactly how omega-3s support gut health, it appears to change the bacterial makeup of the gut microbiome to prioritize healthy bacteria and provide anti-inflammatory compounds. The interaction between the gut microbiome and the anti-inflammatory properties of omega-3s appears to positively affect intestinal mucosal barriers.40
NAG is a chemical related to glucose that helps build joints and connective tissues. It’s primarily found in shellfish, so most supplements with NAG aren’t vegan-friendly. Most of the time, NAG is used to treat IBD, as it creates a biofilm that supports the intestine’s mucus layer.41 This also means there’s a chance it can help with leaky gut symptoms, though research is still ongoing.
Demulcent plants — such as marshmallow root, slippery elm, licorice, and aloe vera — have anti-inflammatory properties; they coat the mucous membranes in your intestines. The additional mucosal coating is thought to protect irritated, sensitive mucosal barriers from extra leakage while they heal. Clinical research on this function is limited, but some studies have shown that demulcents may help optimize gut health in people with IBD.54
Quercetin is the most commonly consumed flavonoid in dozens of plants and foods. As a flavonoid, it adds pigment to plants and has antioxidant and anti-inflammatory properties. It also plays a role in capillary permeability, so increasing your quercetin intake could help keep toxins from a leaky gut out of your bloodstream.42
Best known for its role in skin care, collagen plays a function in maintaining your cell’s structural health. It’s broken down into amino acids during the digestive process, which then help build proteins that support things like tight junctions. Some initial studies show collagen’s effectiveness at improving tight junctions in individuals with IBD, but research on its role in leaky gut is still limited.55
Good leaky gut supplements often combine the above ingredients to provide structural support for your intestinal lining while reinforcing good bacteria in your microbiome, so your body can continue healing long after you take the supplement.
Leaky gut supplements should be generally safe for most healthy adults. However, like all supplements, those for leaky gut are not regulated by the Food and Drug Administration (FDA) in the same way as pharmaceutical medications or food. Manufacturers cannot legally claim that their supplement can cure, diagnose, treat, or prevent any disease.
Since ingredients can vary wildly between leaky gut supplements, make sure to read a product’s Supplement Facts to ensure there are no potential adverse effects for you. Most leaky gut supplements include L-glutamine, which people with a history of liver or kidney disease shouldn’t take.58 Adding glutamine to your daily routine can worsen mental health symptoms such as psychosis, so if you have a history of psychiatric conditions, be cautious when starting a leaky gut supplement.59 Glutamine can also interfere with anti-epileptic medications and epilepsy in general.60
Probiotics are generally safe for most people to take, but as with any supplement, you should reach out to your doctor before beginning a new regimen. However, if you have pancreatitis or a severely compromised immune system (from undergoing chemotherapy, for example), you should take a leaky gut supplement that doesn’t include probiotics.43 That’s because probiotics are still bacteria, and even otherwise beneficial bacteria can pose a risk to the immunocompromised.
Pregnant or lactating people should also avoid leaky gut supplements, as should children.
In addition, don’t mix powdered leaky gut supplements into hot liquids, as L-glutamine deteriorates under heat. Likewise, don’t cook or bake with any leaky gut supplements.
Best overall and best powder
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Terra Origin’s Healthy Gut is a powdered formula specifically designed to taste good and help you feel better. It has a long list of gut-healthy ingredients, including:
Inulin is a prebiotic, though it isn’t marketed as such. It can add a layer of support to your gut, but because the quantity isn’t specified, the dosage here probably isn’t enough to make a big difference in your digestive system. Stevia is likely included to give the powder a little sweetness and boost its flavor. Anecdotal evidence indicates that stevia can cause stomach upset in some people, including bloating and excess gas (which most people are trying to avoid when looking for a leaky gut supplement), though a 2024 study has determined that such symptoms aren’t due to any alteration of the gut microbiome.75
In 2025, Terra Origin Healthy Gut is available in the following seven flavors:
It was previously available in an eighth flavor, Matcha Green Tea, but not anymore.
Terra Origin used to offer some of these flavors in 90-serving containers, as well, but it has since simplified the offerings to 30-serving containers only. There’s also a 21-serving stick pack exclusively in the Berry flavor, a separate vegan formula, and a capsule alternative. The vegan formula has a slightly different ingredient bill, but the L-glutamine and zinc are the same. The capsule provides lower ingredient doses and omits the 5g dose of L-glutamine, so we don’t recommend it as a suitable substitute for the powder or as the best capsule supplement in this guide.
You can order Terra Origin’s Healthy Gut powder as a one-time purchase or on a flexible subscription basis. The same goes for the 21-serving boxes of individual stick packs. Terra Origin previously offered a 10-16% discount on bulk orders of two or three containers, but it isn’t available as of early 2025. Speaking with customer support, we learned the company may bring back the bulk order option later in the year.
Right now, when you purchase directly from Terra Origin, the pricing for both the containers and the stick packs looks like this:
As you can see, the stick packs cost the same as the containers, but they only contain 21 servings, not the 30 servings you get in each container. Ultimately, you end up getting less of the product for the same amount of money thanks to the added packaging involved. The best course of action to ensure consistent daily consumption may be to subscribe to the containers and make one-time purchases of the stick packs. That way, you have your main source of supplement in bulk form and a handful of on-the-go packets if you ever need them.
For subscriptions to either the containers or the stick packs, the delivery intervals are 30, 60, or 90 days. Should you subscribe to the stick packs, you’ll have a supply deficit at month’s end if you use the powder daily.
Terra Origin has a 30-day return policy with free return shipping and a 100% satisfaction guarantee, so no matter how much you’ve tried, you can return your Healthy Gut powder for a full refund as long as it’s within 30 days of purchase. That’s not as long as the guarantee from Gundry MD (90 days), but it’s still better than Revive’s 15-day return policy for unopened items only.
Best budget pick and most potent
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Since L-glutamine has the potential to treat intestinal injuries, a simple glutamine supplement like Revive might make sense for anyone looking for the simplest possible start on their gut repair journey. We’ve created a guide to our favorite glutamine supplements, and Revive Glutamine is among the best.
The studies we’ve looked at have employed doses of glutamine as high as 40g per day with very few adverse effects.56 Glutamine has been effective in these studies at doses as low as 18-20g/day. It’s hard to know exactly why leaky gut supplements are content with what appears to be a market-wide maximum of 5g per serving, which is why going straight to a single-ingredient source might prove beneficial.
Revive Glutamine contains 10g of L-glutamine per serving. It’s an unflavored drink mix you can combine with water or any drink of your choice. It’s also third-party tested, and the results of that testing are available on the Revive website, but it’s blurry and nearly impossible to read.
Revive lacks many of the other common ingredients in leaky gut supplements, like zinc, but you can combine it with a decent multivitamin for less than the cost of some leaky gut supplements.
One 30-serving bottle of Revive Glutamine costs $19.99. Subscriptions are available, but they don’t save you any money; they’re just there for convenience. You could subscribe and save through Amazon, but the product is unavailable as of this writing.
Shipping from Revive is only free on orders of $150 or more — the highest threshold in our guide. The company offers around 40 supplements, as well as apparel and several bundles that can help increase your cost and get you closer to free shipping. But none of those bundles contain Revive Glutamine.
Best capsule
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Designs for Health sells GI Revive as both a capsule and a powder supplement. Here, we're looking at the capsule version because it's a solid option for people who'd rather not deal with powder mixes.
Few capsule-based leaky gut complexes pack as much punch as GI Revive. Here are two areas where it stands out:
Every serving of GI Revive contains 1.5g of L-glutamine. It's far from a clinical dose but more than other capsule supplements for leaky gut. Most competing capsules we've seen deliver around 1g or less. We found one that has 1.85g, but it has zero zinc and only one other ingredient that might do any good for someone's GI health.
Speaking of zinc, GI Revive gives you a hefty dose at 17mg. That's elemental zinc, by the way, and more than what you get from Terra Origin or NatureM.D. The 17mg dose is higher than the Recommended Dietary Allowance but also well below the 40mg Tolerable Upper Intake Level for adults.46 Even when you account for average daily intakes (16.4mg per day among men, 12.6mg among women), a 17mg supplemental dose is low enough to keep most people from tipping over into excessive intake territory.46
Apart from the above, several ingredients in the bill appear in other brands we recommend, and a few at equal or higher doses:
Other ingredients used in GI Revive don’t appear in the other brands discussed in this guide:
Though its formulation is promising, Designs for Health GI Revive falls short of being our top leaky gut supplement for two reasons. First, unlike Terra Origin, it has no copper to offset the risk of copper deficiency posed by its high zinc content. Second, to deliver all of its ingredients in decent dosages, it requires a huge serving size of seven capsules.
Designs for Health GI Revive costs $86.50 as a one-time purchase and $82.17 as a subscription. Subscribers can choose to receive their auto-shipments every one, two, or three months. Shipping is free for orders above $50, and a single container of GI Revive gets you well over the threshold.
Designs for Health is a practitioner-channel company, so customers who purchase directly through the official website will have to create an account and register as patients. Registration requires that you choose one of the following options:
Practitioner here refers to one of the medical professionals affiliated with GI. Choosing a practitioner is part of the checkout process, and you can select any one you want. There's no consultation or further barrier you’ll encounter.
Before you buy, you should know that Designs for Health doesn't have a money-back guarantee, only a limited 30-day return policy. To be eligible for a return, your item must be unopened and must be authorized as a returnable product. If it's accepted, your refund will be less a 20% restocking fee, so the most you'll get back is around $65 or $70. You'll also need to consider the cost of return shipping, which is your responsibility to provide.
Best option that includes probiotics and best money-back guarantee
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Gundry MD is both the brand name and the name and title of the founding physician who develops the formulas sold under its banner, including Bio Complete 3. This supplement is designed to address leaky gut by improving your gut microbiome by way of a probiotic with two additional supporting ingredients.
One serving is two capsules, which Gundry MD recently reduced from four during a slight reformulation (and, presumably, an upgrade in capsule size).
While it isn’t a perfect supplement, Bio Complete 3 has several ingredients that may help your leaky gut heal itself without additional intervention. There are three major ingredients listed:
Sunfiber is a branded prebiotic that provides soluble fiber to your system. It’s low FODMAP (low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols), meaning it’s suitable for those with IBS, IBD, and other sensitivities to FODMAPs. This, alongside Sunfiber’s other benefits, helps it absorb quickly without causing bloating or excess gas.
These are good bacteria that can create lactic acid and help prevent diarrhea and bloating.47 Bifidobacterium bifidum is a recent addition to the Bio Complete 3 formula; Gundry MD doesn’t advertise the balance between it and Bacillus coagulans or state either bacterium’s quantity in colony-forming units (CFU), a widely accepted measurement of probiotic material in the industry. We were able to pry enough information from company reps to learn that there are 2 billion CFU of ProDura in the blend, but Gundry did not provide the CFU for its other probiotic.
This 30% tributyrin formula is a postbiotic, or a beneficial type of waste left behind after your body digests the pre- and probiotics.76 Tributyrin is a triglyceride alternative to butyrate that is easier to absorb and releases more slowly throughout the GI tract.
Bio Complete 3 also contains maltodextrin, a simple carbohydrate that converts to glucose and preserves the supplement, increasing its shelf life.
There are several different ways you can order Bio Complete 3. You can get single or multiple bottles in bulk, and creating a free Gundry MD account unlocks extra savings. We’ve included a chart to help you understand the price differences between your options.
Cost (standard) | Cost with Gundry MD account | Savings | |
---|---|---|---|
One bottle | $70 | $50 | 29% |
Three bottles | $189 | $135 | 29% |
Six bottles | $354 | $255 | 28% |
Gundry MD also offers a subscription program that would save you an additional 10% off every order.
You can get free shipping on every order over $49 (so every one-bottle purchase of Bio Complete 3 will ship free to your home). And if you try it and find it doesn’t agree with you, you can take advantage of Gundry MD’s 90-day money-back guarantee to get all of your money back (minus the cost of return shipping).
Interested in learning more? Check out our full review of Bio Complete 3.
Best for restricted diets
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We recommend Seed DS-01 Daily Synbiotic for people on restricted diets because it's free of binders, preservatives, and numerous ingredients that can trigger allergic reactions or GI distress, including:
What it is, exactly, is a combination of probiotics with a prebiotic (Indian pomegranate). It contains 24 bacterial strains, 16 of which target gut immunity and barrier integrity. Specifically, it delivers a total of 53.6 billion AFU (active fluorescent units, a potentially more accurate method of measuring viable bacterial colonies), with 37 billion of them being aimed at GI health.67
Several of Seed's strains have strong scientific support for their gut-health benefits — for example:
Lactiplantibacillus plantarum LP1 may be able to antagonize pathogenic overgrowth as well as improve the gastric barrier, reduce inflammation, and prevent oxidative stress.73
The above list doesn’t cover everything contained in the Seed capsule, but it should give you a sense of what DS-01 can do for your gut health.
Moreover, DS-01 leverages a proprietary technology that can increase the amount of viable bacteria that reaches your GI tract. Called ViaCap, it’s essentially a capsule within a capsule. The outer capsule protects the inner one as the whole thing travels through the harsh gastric environment.
Apart from products purchased through its Amazon storefront or brick-and-mortar stores, Seed is a subscription-only service. A one-month supply of its DS-01 Daily Synbiotic, as well as every subsequent refill, costs $49.99 (around $1.67 per serving). However, you can get a discounted rate per unit if you purchase in three- or six-month bulk orders, as illustrated by this table:
3-month supply (10% discount) | 6-month supply (15% discount) | |
---|---|---|
Total | $134.97 | $254.95 |
Per month | $44.99 | $42.49 |
Per serving | $1.50 | $1.42 |
As a cherry on top, all U.S. orders ship for free.
If you try Seed and decide it isn’t for you, then you have 30 days to take advantage of its money-back guarantee. It’s a no-questions-asked policy, but it applies only to your first order. Also, you’re responsible for the return shipping.
Insider Tip: To approximate a one-time purchase with Seed, just cancel your subscription before the next billing cycle. There’s no penalty for it. Alternatively, you can purchase a one-month supply at Target, albeit at a higher price.
GutConnect 365 is one of the two supplements on our list that provides 5mg of L-glutamine per serving. As such, it targets tight junction regulation and anti-inflammatory signaling, even if 5g is less than clinical recommendations. In comparison, most studies use about 0.5g per kg of body weight, and Revive Glutamine delivers a 10g dose per serving.48
Here are all the ingredients you can find in GutConnect 365:
While maitake mushrooms might not have the most scientific evidence pointing to gut support, they do add beneficial fiber to the powder.50
GutConnect 365 comes in both chocolate and vanilla flavors. The powder is completely vegan, gluten-free, soy-free, and non-GMO. NatureM.D. advertises that it can work as a meal replacement, but with only ten calories per serving, that seems like false advertising.
NatureM.D. can be purchased directly from the company. You’ll find it on popular marketplaces such as Amazon, but since there appears to be no official storefront, its authenticity can’t be verified. A one-time purchase costs $54, while a subscription is $48.60 (a 10% discount).
There used to be a bulk order option that could be paired with a subscription plan, but it’s no longer available.
NatureM.D. provides free shipping on most orders in the U.S. If you or your gut isn’t happy with GutConnect 365, you can return it for a full refund within 30 days of purchase, even if you’ve opened and tried it. It’s not a long guarantee by any means, but it’s better than Revive’s, and it could be long enough for many customers to know whether the supplement is having any effect.
If you’re not sure a leaky gut supplement is right for you, there are several other options you can try to solve your GI problems. Some may require a trip to the doctor’s office, but a few you can take advantage of from the comfort of your home.
We’ve laid out several of them below.
Investigating suspicious symptoms is always a good choice. You can complete some tests at home, like a gut microbiome test or food sensitivity testing, or you can go to your doctor’s office for an endoscopy to check for more severe problems like celiac or Crohn’s disease. Since leaky gut symptoms overlap heavily with other GI diseases — and sometimes leaky gut is a symptom of a larger GI disease — ruling out other problems should generally be your first step.
Taking probiotics on their own can massively improve your gut health, including leaky gut symptoms.52 The beneficial bacteria can help to heal the mucosal wall by promoting mucus secretion and tightening junctions through increased zonulin.57 They also help to break down food more efficiently, meaning you’ll take in more nutrients from what you’re eating. Some of the gut microbiome testing brands we recommend, like Viome, will actually tailor custom probiotics to your unique microbiome needs.
We are what we eat, so following a more gut-healthy diet can make a difference when there isn’t a clear answer to your symptoms. That means consuming less refined sugar, saturated fat, alcohol, and caffeine and eating more whole grains and high-fiber foods. If you need guidance on changing your diet, you can speak to a gastroenterologist or nutritionist or get recommendations from at-home microbiome testing companies.
Post-Thanksgiving dinner walks aren’t just to get away from your family for a few minutes. Research shows that walking for 15-20 minutes after eating can help stimulate your stomach and intestines, helping your body digest food more efficiently.53
Sources
Innerbody uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Almario, C. V., Ballal, M. L., Chey, W. D., Nordstrom, C., Khanna, D., & Spiegel, M. R. (2018). Burden of Gastrointestinal Symptoms in the United States: Results of a Nationally Representative Survey of Over 71,000 Americans. The American Journal of Gastroenterology, 113(11), 1701.
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