The medial superior genicular artery is one of the branches of the popliteal artery. It passes ahead of the semimembranosus and semitendinosus, which are two hamstring muscles. It flows on top of the medial head of the gastrocnemius, and below the third hamstring muscle, the tendon of the adductor magnus.
It separates into two branches. One branch serves the vastus medialis and merges with the medial inferior genicular and highest genicular arteries. The other branches out near the femur's surface, serving the femur as well as the knee-joint with blood that's oxygenated. The lateral superior genicular artery then connects with it.
The medial superior genicular artery is often small in size. This circumstance is related to an increase in the size of the highest genicular.